METHOD OF OBTAINING HYPERIMMUNE SERUM AGAINST SWINE HEMOPHILOSIS, STREPTOCOCCOSIS, AND PASTEURELLOSIS

摘要

FIELD: veterinary science. ^ SUBSTANCE: invention relates to veterinary science. The method includes preparing an antigen from inactivated and concentrated Pasterella multocida serotypes A, B and D, Haemophilus pleuropneumoniae serotypes I and II, Streptococcus suis serotype II (Castel strain) and administering initial immunisation and hyperimmunisation with increasing antigen doses followed by blood taking and end product recovery. Oxen are used as producers and hyperimmunisation is administered in 7 to 10 intramuscular injections with a total dose of 1800-2400 billion microbial bodies of each antigen at 2-3 days' intervals. Initial immunisation is administered hypodermically to different body areas two times with 10-15 billion microbial bodies injected at first and 20-25 billion microbial bodies injected in 14 days plus 10 cm3 aluminium hydroxide. ^ EFFECT: method is simple and time-saving and yields 3,2-3,5 times more serum. ^ 2 tbl, 4 ex