发明名称 |
ADJUVANT ACTIVITIES OF MUTANTS OF LT-IIa AND LT-IIb ENTEROTOXIN LACKING BINDING TO GANGLIOSIDE |
摘要 |
The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.
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申请公布号 |
US2009136535(A1) |
申请公布日期 |
2009.05.28 |
申请号 |
US20080265516 |
申请日期 |
2008.11.05 |
申请人 |
CONNELL TERRY D;RUSSELL MICHAEL W;NAWAR HESHAM;ARCE SERGIO |
发明人 |
CONNELL TERRY D.;RUSSELL MICHAEL W.;NAWAR HESHAM;ARCE SERGIO |
分类号 |
A61K39/02;A61K9/14;A61K39/108;A61K39/39;A61K45/00;A61L9/04;C12N |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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