| 摘要 |
PROBLEM TO BE SOLVED: To provide a practical method for producing glycyrrhizin and its derivative by chemical synthesis. SOLUTION: Glycyrrhizin is chemically synthesized in a short step and in high yield, by a two-stage glycosidation wherein a specific monosaccharide having a protected hydroxyl group which includes bonding the monosaccharide to a hydroxyl group bonding to the 3-carbon atom of glycyrrhetinic acid, to perform glycosidation, and deprotecting the specific hydroxyl group of the monosaccharide after the glycosidation and the rebonding of the monosaccharide used in the glycosidation, and deprotecting and oxidizing the hydroxyl group of the sugar part of the resultant compound. COPYRIGHT: (C)2009,JPO&INPIT
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