发明名称 |
MONOCLONAL ANTIBODY WHICH BINDS MET IN FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUES AND RELATED METHODS |
摘要 |
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided. |
申请公布号 |
WO2009029591(A3) |
申请公布日期 |
2009.05.28 |
申请号 |
WO2008US74249 |
申请日期 |
2008.08.25 |
申请人 |
VAN ANDEL RESEARCH INSTITUTE;CAO, BOLIANG;VANDE WOUDE, GEORGE F.;KNUDSEN, BEATRICE S.;ZHAO, PING XU |
发明人 |
CAO, BOLIANG;VANDE WOUDE, GEORGE F.;KNUDSEN, BEATRICE S.;ZHAO, PING XU |
分类号 |
C07K16/28;C12N5/20;G01N33/577 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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地址 |
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