发明名称 |
PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE |
摘要 |
A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.
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申请公布号 |
US2009136555(A1) |
申请公布日期 |
2009.05.28 |
申请号 |
US20070294372 |
申请日期 |
2007.03.22 |
申请人 |
CROWLEY MICHAEL M;KEEN JUSTIN M;KOLENG JOHN J;ZHANG FENG |
发明人 |
CROWLEY MICHAEL M.;KEEN JUSTIN M.;KOLENG JOHN J.;ZHANG FENG |
分类号 |
A61F2/04;A61K9/00;A61K9/70;A61K31/56 |
主分类号 |
A61F2/04 |
代理机构 |
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主权项 |
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地址 |
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