MULTILAYERED CONTROLLED RELEASE PHARMACEUTICAL DOSAGE FORM

摘要

This invention is directed to a multilayered controlled release pharmaceutic al dosage form. More particularly the dosage form is adapted for water soluble drugs and comprises a plurality of coated particle s wherein each has multiple layers about a core containing a drug active whereby the drug containing core and at least one other layer of drug active is overcoated with a controlled release barrier layer and preferably an outer layer of additional drug is adapted for immediate re lease to preferably provide one immediate releasing layer and at least two controlled releasing layers of a water soluble drug from the mu ltilayered coated particle.