MULTISTATE AFFINITY LIGANDS FOR THE SEPARATION AND PURIFICATION OF ANTIBODIES, ANTIBODY FRAGMENTS AND CONJUGATES OF ANTIBODIES AND ANTIBODY FRAGMENTS

摘要

Separation of antibodies, antibody fragments, and conjugates thereof using multistate affinity ligands rationally designed and selected to undergo analytically and functionally definable conformational transitions from a first affinity state under a first operator-defined environmental condition to a second affinity state under a second operator-defined environmental condition.