发明名称 |
BACTERIAL ANTIGENS AND USES THEREOF |
摘要 |
<p>Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mould Dictyostelium discoideum and used to specifically degrade lipopolysaccharide (LPS). Enzymatic degradation permits residues of the LPS molecule, including immunogenic epitopes of the core oligosaccharide portion of the LPS, to remain unmodified during this enzymatic removal of fatty acids from the lipid A region of the LPS molecule.</p> |
申请公布号 |
EP1996715(A4) |
申请公布日期 |
2009.05.20 |
申请号 |
EP20060817659 |
申请日期 |
2006.11.23 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
COX, ANDREW;NEELAMEGAN, DHAMODHARAN;SCHOENHOFEN, IAN;ST. MICHAEL, FRANK;RICHARDS, JAMES, C. |
分类号 |
C12P19/04;A61K38/14;A61K39/02;A61K39/095;A61K39/102;A61P31/04;C12N9/24 |
主分类号 |
C12P19/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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