发明名称 |
ANTI-LYMPHOTOXIN-BETA RECEPTOR ANTIBODIES AS ANTI-TUMOR AGENTS |
摘要 |
This invention relates to compositions and methods useful for activating LT-beta receptor signaling, which in turn elicits potent anti-proliferative effects on tumor cells. More particularly, this invention relates to lymphotoxin heteromeric complexes formed between lymphotoxin-a and multiple subunits of lymphotoxin-beta, which induce cytotoxic effects on tumor cells in the presence of lymphotoxin-beta receptor activating agents. Also within the scope of this invention are antibodies directed against the lymphotoxin-beta receptor which act as lymphotoxin-beta receptor activating agents alone or in combination with other lymphotoxin-beta receptor activating agents either in the presence or absence of lymphotoxin-a/beta complexes. A screening method for selecting such antibodies is provided. This invention also relates to compositions and methods using cross-linked anti-lymphotoxin-beta receptor antibodies either alone or in the presence of other lymphotoxin-beta receptor activating agents to potentiate tumor cell cytotoxicity.
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申请公布号 |
US2009123421(A1) |
申请公布日期 |
2009.05.14 |
申请号 |
US20080262794 |
申请日期 |
2008.10.31 |
申请人 |
BIOGEN IDEC MA INC. |
发明人 |
BROWNING JEFFREY L.;MEIER WERNER;BENJAMIN CHRISTOPHER D. |
分类号 |
A61K38/21;A61K38/00;A61K38/16;A61K38/19;A61K39/395;C07K14/525;C07K14/715;C07K16/18;C07K16/24;C07K16/28;C12Q1/02 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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