发明名称 |
NUCLEIC ACID COMPLEX AND NUCLEIC ACID DELIVERY COMPOSITION |
摘要 |
The present invention provides a nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid, such as siRNA or the like, in a cell; and a nucleic acid delivery composition that can efficiently deliver the nucleic acid complex into a cell. A nucleic acid complex with low toxicity and high safety that can persistently maintain a nucleic acid in a cell can be obtained by forming a complex using a nucleic acid to be introduced into a cell, and a highly branched cyclic dextrin. Moreover, when a carrier comprising (A) a diacylphosphatidylcholine, (B) cholesterol and/or a derivative thereof, and (C) an aliphatic primary amine is used as a nucleic acid delivery carrier to introduce the nucleic acid complex into a cell, the safety, the efficiency of intracellular delivery, and the persistence of the nucleic acid in the cell can be further improved.
|
申请公布号 |
CA2704236(A1) |
申请公布日期 |
2009.05.14 |
申请号 |
CA20082704236 |
申请日期 |
2008.11.06 |
申请人 |
OTSUKA PHARMACEUTICAL CO., LTD.;TAKEUCHI, HIROFUMI |
发明人 |
TOZUKA, YUICHI;HIRA, YASUYUKI;TOYOBUKU, HIDEKAZU;TAKEUCHI, HIROFUMI |
分类号 |
A61K9/127;A61K47/40;A61K47/48;A61K48/00;C12N15/87 |
主分类号 |
A61K9/127 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|