发明名称 |
Transgenic animal model for alzheimer's disease |
摘要 |
Provided is a novel APP (amyloid precursor protein) transgenic non-human animal modeling in vivo the pathophysiological effects and effects on cognitive behavior of early intraneuronal and extracellular brain parenchymal amyloid-beta (Abeta) deposition and cerebral amyloid angiopathy associated with brain microhemorrhages and reduced vasoreactivity and blood flow. Furthermore, methods of screening for therapeutic or diagnostic agents useful in the treatment or diagnosis of Alzheimer's disease, in particular for improving blood flow to the brain are provided as well as the corresponding therapeutic methods.
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申请公布号 |
US2009117120(A1) |
申请公布日期 |
2009.05.07 |
申请号 |
US20080157664 |
申请日期 |
2008.06.11 |
申请人 |
GRIMM JAN;NITSCH ROGER;KNOBLOCH MARLEN;KONIETZKO UWE;RUDIN MARKUS;MUGGLER THOMAS;KRANZ FELICITAS |
发明人 |
GRIMM JAN;NITSCH ROGER;KNOBLOCH MARLEN;KONIETZKO UWE;RUDIN MARKUS;MUGGLER THOMAS;KRANZ FELICITAS |
分类号 |
A61K39/395;A01K67/027;A61B10/00;A61P25/28;C12N15/12;C12N15/85 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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