摘要 |
PROBLEM TO BE SOLVED: To provide a new inhibitor for AGE (advanced glycation end-product) formation. SOLUTION: The invention relates to the inhibitor for AGE formation consisting of an arylcarboxylic acid derivative represented by general formula (1) or its salt or their solvates as an active ingredient, [in the formula, R<SP>1</SP>is a 1-6C alkyloxy group, a 3-14C (substituted) carbon ring or a 5-14 membered (substituted) heterocyclic group, A and X are each independently a single bond or a 1-6C alkylene group, Y is a single bond, -O-(1-6C alkylene group)- group or -NH-(1-6C alkylene group)-, Z is an oxygen atom or N-R<SP>2</SP>(wherein the R<SP>2</SP>is a 1-6C alkyl group or a (1-6C alkylene group)-(CO)<SB>n</SB>-R<SP>3</SP>, R<SP>3</SP>is NR<SP>4</SP>R<SP>5</SP>, a piperidino group or a morpholino group, R<SP>4</SP>and R<SP>5</SP>are each the same or different H, or a 1-6C alkyl group, and n is 0 or 1)]. COPYRIGHT: (C)2009,JPO&INPIT
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