STREPTOCOCCUS M PROTEIN, IMMUNOGENIC FRAGMENTS, NUCLEIC ACIDS AND METHODS OF USE

摘要

Isolated M proteins, or M-like proteins, of Streptococcus iniae, encoding nucleic acids, genetic constructs and antibodies which bind the isolated M proteins are provided. Also provided are isoforms and/or fragments of the M proteins, or M-like proteins, that display reduced fibrinogen binding. The isolated M proteins, antibodies and encoding nucleic acids maybe useful for diagnosis, immunization and/or therapy of Streptococcus iniae infections of animals such as fish and humans.