PEPTIDE VACCINE USING MIMIC MOLECULE OF AMYLOID ß-PEPTIDE

摘要

In the invention, a peptide capable of inducing production of an antibody specific to abnormal amyloid ß-peptide is found from mimic peptides of amyloid ß-peptide and the resulting peptide is used as a vaccine or an immunogen. The invention relates to a pharmaceutical composition comprising a peptide having 8 to 30 amino acid residues containing at least one amino acid sequence of an amino acid sequence represented by the following formula (I): Tyr-Gly-Thr-Lys-Pro-Trp-Met (I) and an amino acid sequence represented by the following formula (II): Leu-Asp-Ile-Phe-Ala-Pro-Ile (II) or a conjugate of the peptide and a carrier.