GALACTOSE DERIVATIVE, DRUG CARRIER AND MEDICINAL COMPOSITION

摘要

The object of the present invention is to provide a novel and useful galactose derivative, which is a component of a drug carrier by which a medicine can be efficiently transferred into the liver, a drug carrier comprising the derivative, and a pharmaceutical composition comprising the drug carrier and a medicine.

The present invention relates to a galactose derivative represented by the following general formula (I), a drug carrier comprising the derivative and a cationic lipid, and a pharmaceutical composition comprising the carrier and a medicine (preferably a double-stranded RNA, a double-stranded DNA, an oligo nucleic acid).
<Chemistry id="chema01" num="0001"><Image id="ia01" he="36" wi="50" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
wherein, R<Sup>1</Sup> represents hydrogen, an alkyl having 1 to 10 carbons which may be substituted or 1-(D)-deoxylactito-1-yl; R<Sup>2</Sup> represents a saturated or unsaturated fatty acid residue having 10 to 30 carbon atoms.