发明名称 |
GTPASE INHIBITORS AND METHODS OF USE AND CRYSTAL STRUCTURE OF RAC-1 GTPASE |
摘要 |
The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools. |
申请公布号 |
WO2007016539(A3) |
申请公布日期 |
2009.04.02 |
申请号 |
WO2006US29873 |
申请日期 |
2006.07.31 |
申请人 |
CHILDREN'S HOSPITAL MEDICAL CENTER;THE STATE UNIVERSITY OF NEW YORK, STONY BROOK UNIVERSITY;ZHENG, YI;NASSAR, NICOLAS;SKOWRONEK, KARLHEINZ, R. |
发明人 |
ZHENG, YI;NASSAR, NICOLAS;SKOWRONEK, KARLHEINZ, R. |
分类号 |
A61K31/505 |
主分类号 |
A61K31/505 |
代理机构 |
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