发明名称 |
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates |
摘要 |
<p>The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results on the expression of non-bovine antibodies, preferably human antibodies.</p> |
申请公布号 |
EP2042594(A1) |
申请公布日期 |
2009.04.01 |
申请号 |
EP20080016978 |
申请日期 |
2001.11.16 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
ROBL, JAMES M.;KUROIWA, YOSHIMI;TOMIZUKA, KAZUMA;ISHIDA, ISAO |
分类号 |
C12N15/00;A01K67/027;A01K67/033;C07K14/47;C07K16/04;C07K16/18;C12N5/10;C12N9/10;C12N15/02;C12N15/09;C12N15/85;C12P21/00;C12P21/08 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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