ВЫДЕЛЕННОЕ АНТИТЕЛО БЕЗ ФУКОЗИЛЬНЫХ ОСТАТКОВ ПРОТИВ СПЕЦИФИЧЕСКОГО МЕМБРАННОГО АНТИГЕНА ПРОСТАТЫ (PSMA), КЛЕТКА-ХОЗЯИН, СПОСОБ ИНГИБИРОВАНИЯ РОСТА КЛЕТОК, ЭКСПРЕССИРУЮЩИХ PSMA, И СПОСОБ ИНГИБИРОВАНИЯ РОСТА ОПУХОЛЕВЫХ КЛЕТОК

摘要

The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.