| 摘要 |
<p>#CMT# #/CMT# Topical composition (A), contains as active ingredient, one or more fragments (I) of hyaluronate with molecular weight 50-750 kD. #CMT#ACTIVITY : #/CMT# Dermatological. #CMT#MECHANISM OF ACTION : #/CMT# (I) increases the number of proliferating cells, particularly fibroblasts, in the epidermis and dermis, so induce epidermal thickening. A standard cosmetic vehicle contained 0.2 % hyaluronate fragments of molecular weight 50-250 kD and was applied twice daily to the skin of SKH1 hairless mice. After an unspecified treatment time, epidermal thickness and the number of proliferating cells were determined. The mean thickness was 0.32 mm (compare 0.07 mm in controls) and the number of cells (per microscope field) was 257 compared with 96 in controls. Also the mean number of proliferating cells (positive for the marker Ki67; per field) was 96 in the epidermis and 5 in the dermis; compare 26 and 0.95 in controls. #CMT#USE : #/CMT# (A) are used, in cosmetics and dermatology, to prevent or improve skin wrinkles or dry skin; to maintain firmness and humidity; to prevent and treat dermatitis associated with atrophy of skin tissue or which requires improved hydration; to reduce atrophy caused e.g. by treatment with corticoids; to control skin ageing where light-induced or not; to boost cellular activity of the (epi)dermis, and to improve elasticity of the skin. #CMT#ADVANTAGE : #/CMT# When combined with a retinoid, (I) show a synergistic effect on hyaluronic acid synthesis in fibroblasts. #CMT#PHARMACEUTICALS : #/CMT# Preferred Materials: (I) has molecular weight 50-250 or 250-750 kD. Preferred Composition: This may also contain at least one retinoid (II), particularly retinol (or its isomers); retinal or retinoic acid (or its isomers and esters), optionally also standard colors, silicone oils, antiseptics, plant oils, antioxidants, thickeners and UV absorbers etc.</p> |
