发明名称 |
ENZYME REGULATING ETHER LIPID SIGNALING PATHWAYS |
摘要 |
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly elevated in aggressive cancer cells, serves as a central node in an ether lipid signaling network that bridges platelet-activating factor and the lysophospholipids. Biochemical studies confirmed that the active protein regulates this pathway by hydrolyzing the metabolic intermediate 2-acetyl monoalkylglycerol. Inactivation of the active protein disrupted ether lipid metabolism in cancer cells and impaired cell migration and tumor growth in vivo.
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申请公布号 |
US2009068107(A1) |
申请公布日期 |
2009.03.12 |
申请号 |
US20070866349 |
申请日期 |
2007.10.02 |
申请人 |
THE SCRIPPS RESEARCH INSTITUTE |
发明人 |
CRAVATT BENJAMIN F.;CHIANG KYLE P.;NIESSEN SHERRY;SAGHATELIAN ALAN |
分类号 |
A61K49/00;A61K31/27;A61P31/00;C12N5/06;C12Q1/68;G01N33/00 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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