发明名称 |
COMPOSITIONS COMPRISING NANOPARTICULATE NAPROXEN AND CONTROLLED RELEASE HYDROCODONE |
摘要 |
<p>The invention relates to a compositions comprising a nanoparticulate naproxen composition in combination with a multiparticulate modified release hydrocodone composition that, upon administration to a patient, delivers a hydrocodone in a bimodal or multimodal manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component; the first component comprising a first population of hydrocodone - comprising particles and the at least one subsequent component comprising a second population of hydrocodone-comprising particles, wherein the combination of the components exhibit a bimodal or multimodal release profile. The invention also relates to a solid oral dosage form comprising such a combination composition.</p> |
申请公布号 |
EP2032137(A2) |
申请公布日期 |
2009.03.11 |
申请号 |
EP20070799011 |
申请日期 |
2007.06.25 |
申请人 |
ELAN PHARMA INTERNATIONAL LIMITED |
发明人 |
STARK, PAUL;DEVANE, JOHN;FANNING, NIALL;LIVERSIDGE, GARY;JENKINS, SCOTT;SINGH-REKHI, GURVINDER |
分类号 |
A61K31/4375;A61K9/22;A61K31/12 |
主分类号 |
A61K31/4375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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