发明名称 Fluoro substituted 2-oxo-azepan derivatives
摘要 The invention relates to compounds of general formula wherein R1, R2, R3/R3', R4/R4' and R5/R5' are as defined in the specification and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds are gamma-secretase inhibitors which can be useful in the treatment of Alzheimer's disease or common cancers including, but not limited to, cervical carcinomas and breast carcinomas and malignancies of the hematopoietic system.
申请公布号 US7501406(B2) 申请公布日期 2009.03.10
申请号 US20060500662 申请日期 2006.08.08
申请人 HOFFMANN-LA ROCHE INC. 发明人 FLOHR ALEXANDER;GALLEY GUIDO;JAKOB-ROETNE ROLAND;KITAS ERIC ARGIRIOS;WOSTL WOLFGANG
分类号 C07D223/12;A61K31/55;C07D401/12;C07D413/12 主分类号 C07D223/12
代理机构 代理人
主权项
地址