发明名称 |
СПОСОБ ЛЕЧЕНИЯ РАКА, УСТОЙЧИВОГО К ГЕФИТИНИБУ |
摘要 |
The present invention is directed to methods for the treatment of gefitinib and/or erlotinib resistant cancer. An individual with cancer is monitored for cancer progression following treatment with gefitinib and/or erlotinib. Progression of the cancer is indicative that the cancer is resistant to gefitinib and/or erlotinib. Once progression of cancer is noted, the subject is administered a pharmaceutical composition comprising an irreversible epidermal growth factor receptor (EGFR) inhibitor. In preferred embodiments, the irreversible EGFR inhibitor is EKB-569, HKI-272 and HKI-357. |
申请公布号 |
RU2007132902(A) |
申请公布日期 |
2009.03.10 |
申请号 |
RU20070132902 |
申请日期 |
2006.02.02 |
申请人 |
ДЗЕ ДЖЕНЕРАЛ ХОСПИТАЛ КОРПОРЕЙШН (US);УАЙТ (US) |
发明人 |
ХАБЕР Дэниел (US);БЕЛЛ Дафис Уинифред (US);СЕТТЛМЭН Джеффри Е. (US);СОРДЕЛЛА Раффаэлла (US);ГОУДИН-ХЕЙМАНН Над Дж. (US);КВАК Юнис Л. (US);РАБИНДРАН Сридхар Кришна (US) |
分类号 |
A61K38/17 |
主分类号 |
A61K38/17 |
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