4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES

摘要

The invention provides quinazoline compounds of the formula:or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases,wherein:R is C-Cstraight or branched alkyl, optionally substituted by one or more halogens;Rand Rare independently selected from H, C-Calkyl, F, Br, 1 or Cl;X is O, S or NH; andthe dashed lines designated a and b each indicate an optional double bond, with the proviso that only a single double bond a or b exists in one compound.