发明名称 |
Benzamide compounds useful as histone deacetylase inhibitors |
摘要 |
The invention concerns benzamide compounds of formula (I), wherein R1 is a C-linked pyrazole ring, which is optionally substituted by one or more groups selected from C1-4alkyl, C3-4cycloalkyl, C1-4alkoxy and C3-4cycloalkoxy; or a pharmaceutically acceptable salt or pro-drug form thereof. The invention also concerns processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumors or other proliferative conditions, which are sensitive to the inhibition of histone deacetylase (HDAC). |
申请公布号 |
ZA200803096(B) |
申请公布日期 |
2009.02.25 |
申请号 |
ZA20080003096 |
申请日期 |
2008.04.08 |
申请人 |
ASTRAZENECA AB. |
发明人 |
ANDREWS, DAVID MICHAEL;TURNER, ANDREW;STOKES, ELAINE SOPHIE ELIZABETH;WARING, MICHAEL JAMES |
分类号 |
A61K;A61P;C07D;C07D401/06 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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