PREDICTIONS OF RESPONSIVENESS TO EGFR INHIBITORS

摘要

Coordinated over-expression of the EGFR pathway predicts susceptibility to EGFR inhibitors in cancer. This suggests that a phenomenon of pathway- rather than oncogene-addiction predicts vulnerability to EGFR inhibition in cancer. This demonstrates the powerful value of unbiased systems biology approaches in drug development and have important implications^for the management of use of these agents in cancers.