COLLOIDAL VECTORS WITH POLYAMINOACID STRUCTURE FOR ORAL RELEASE OF PEPTIDES AND PROTEINS AND METHOD FOR THEIR PRODUCTION

摘要

The invention concerns delivery systems for the release of active ingredients, specifically peptides and proteins, by means of their incorporation in nanoparticles, nano-aggregates or complexes based on suitably derivatized synthetic polyaminoacids, consisting of copolymers with a polyaspartamide backbone (specifically, alpha.beta-poly-hydroxyethyl-aspartamide or PHEA) to which hydrophobic functionalities, iopisable functionalities and thiol functional- ities in side chains are covalently linked, each individually or in combination with each other. Such polymer systems are proposed to release peptide drugs or pro¬ teins, such as insulin, from oral dosage forms in an effective manner, and in order to increase the physicochemicai stability of proteins in liquid or solid pharmaceutical dosage forms.