发明名称 |
BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS |
摘要 |
The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use as medicaments. Compounds of general formula (I) have high affinity for the dopamine D3 and serotonin (5-Hydroxytryptamine; 5-HT) 5-HT2A receptors and are effective in the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
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申请公布号 |
US2009042943(A1) |
申请公布日期 |
2009.02.12 |
申请号 |
US20080184272 |
申请日期 |
2008.08.01 |
申请人 |
GOBBI LUCA;JAESCHKE GEORG;RODRIGUEZ SARMIENTO ROSA MARIA;STEWARD LUCINDA |
发明人 |
GOBBI LUCA;JAESCHKE GEORG;RODRIGUEZ SARMIENTO ROSA MARIA;STEWARD LUCINDA |
分类号 |
A61K31/445;A61P25/18;C07D211/32 |
主分类号 |
A61K31/445 |
代理机构 |
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