| 发明名称 |
NEW PROTEIN AND METHOD FOR PRODUCING THE SAME |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a new protein and a method for producing the same. <P>SOLUTION: The new protein binds specifically to the osteoclastogenesis inhibitory factor (OCIF) and has high affinity thereto. The new protein can be obtained by preparing a cell membrane fraction from osteoblast-like cell membranes cultured in the presence of a bone absorption-accelerating factor or stroma cells derived from bone marrow, solubilizing a membrane protein by a surfactant and purifying by using an OCIF-immobilized affinity column. By using the protein, screening of physiologically active substances can be performed or an antibody against this protein can be obtained. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
| 申请公布号 |
JP2009013177(A) |
申请公布日期 |
2009.01.22 |
| 申请号 |
JP20080191860 |
申请日期 |
2008.07.25 |
| 申请人 |
DAIICHI SANKYO CO LTD |
发明人 |
YAMAGUCHI KYOJI;YASUDA NAOTAKA;NAKAGAWA NOBUAKI;SHIMA NOBUYUKI;KINOSAKI MASAHIKO;TSUDA HIDEYORI;GOTO MASAAKI;YANO KAZUKI;TOMOYASU MASAHIRO;KOBAYASHI FUMIE;WASHIDA NAOHIRO;TAKAHASHI KEN;MORINAGA TOMONORI;TOO KANJI |
| 分类号 |
C07K14/715;C07K16/18;A61K;A61K38/00;A61K39/395;A61K45/00;A61P3/14;A61P19/00;A61P19/02;A61P19/08;A61P19/10;A61P29/00;B01J20/281;C07K;C07K1/22;C07K14/47;C07K14/525;C07K14/705;C07K16/28;C12N;C12N5/10;C12N5/20;C12N15/02;C12N15/09;C12N15/12;C12P;C12P21/02;C12P21/08;C12Q;G01N;G01N30/88;G01N33/15;G01N33/50;G01N33/53;G01N33/543;G01N33/566;G01N33/577 |
主分类号 |
C07K14/715 |
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