发明名称 |
SINGLE CHAIN, MULTIPLE ANTIGEN-BINDING MOLECULE, ITS PREPARATION AND USE |
摘要 |
<p>Single-chain molecule (I) that binds multiple antigens comprises two variable domains of heavy immunoglobulin chains (VH), having specificities A and B and two variable domains of light chains (VL), also with specificities A and B. The domains are provided as two VH-VL constructs which are attached via a peptide (P). Any VH and VL may be replaced by their functional fragments. Independent claims are also included for the following: (1) nucleic acid (II) encoding (I); (2) vectors containing (II); (3) cells containing (II) or the vectors; (4) recombinant production of (I) by culturing these cells; (5) pharmaceutical composition containing (I), (II), the vectors or cells; and (6) diagnostic composition containing (I). ACTIVITY : Anticancer; antiviral; antibacterial; antimalarial; antiinflammatory. MECHANISM OF ACTION : Specific binding interaction.</p> |
申请公布号 |
PT952218(E) |
申请公布日期 |
2009.01.22 |
申请号 |
PT19990106176T |
申请日期 |
1999.04.08 |
申请人 |
AFFITECH AS |
发明人 |
ROLF MULLER;ROLAND KONTERMANN;HANS-HARALD SEDLACEK, PROF. DR. |
分类号 |
C12N15/00;C12N15/13;A61K31/00;A61K35/74;A61K35/76;A61K38/00;A61K39/00;A61K39/395;A61K47/48;A61K48/00;A61P7/00;A61P25/00;A61P31/00;A61P35/00;A61P37/00;C07K16/00;C07K16/30;C07K16/40;C07K16/46;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/62;C12N15/70;C12N15/85;G01N33/53;G01N33/577 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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