发明名称 |
MATRIX METALLOPROTEASE TARGETING NUCLEIC ACIDS |
摘要 |
<p>A reporter conjugate for non-invasive detection (e.g., imaging) of matrix metalloprotease (MMP) gene expression in vivo is disclosed. The conjugate includes a targeting nucleic acid linked to a contrast agent, such as a paramagnetic label that can be used with magnetic resonance (MR) imaging. The targeting nucleic acid can be an antisense strand that hybridizes to a portion of a messenger RNA encoded by the gene whose expression is to be imaged. In some embodiments, the contrast agent is a chelated metal such as gadolinium or dysprosium. The invention also features methods to detect MMP gene expression in various tissues, including the brain.</p> |
申请公布号 |
WO2009012359(A2) |
申请公布日期 |
2009.01.22 |
申请号 |
WO2008US70277 |
申请日期 |
2008.07.17 |
申请人 |
THE GENERAL HOSPITAL CORPORATION;LIU, PHILIP KUOCHERNG;LIU, CHRISTINA HUANG |
发明人 |
LIU, PHILIP KUOCHERNG;LIU, CHRISTINA HUANG |
分类号 |
G01N24/08;C12Q1/68;G01N33/48 |
主分类号 |
G01N24/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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