COLLAGEN SCAFFOLD MODIFIED BY COVALENT GRAFTING OF ADHESION MOLECULES, ASSOCIATED METHODS AND USE THEREOF FOR CARDIOVASCULAR AND THORACIC CELL THERAPY AND CONTRACTILE TISSUE ENGINEERING

摘要

The invention relates to materials and methods for improving the biological properties and electromechanical performance of collagen scaffolds used for cell transplantation, comprising the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously. The grafting of adhesion molecules to collagen matrices renders same suitable for use in vascular and cardiothoracic surgery/medicine, as well as in cell therapy for the heart and in artificial heart muscle engineering. The invention also relates to a simple method for grafting and optimising the presentation of adhesion peptides or biological agents when the scaffold is made from collagen and/or contains accessible thiol, amine or carboxyl groups.