METHOD FOR THE PREPARATION OF TUBE-TYPE POROUS BIODEGRADABLE SCAFFOLD HAVING A DOUBLE-LAYERED STRUCTURE FOR VASCULAR GRAFT

摘要

A manufacturing method of a tube type porous scaffold of a double-film structure for artificial blood vessel is provided to have excellent interconnectivity between air bubbles, mechanical stability, transfection and breeding efficiency and to prevent fistula blood at the hypertension state. A manufacturing method of a tube type porous scaffold of a double-film structure for artificial blood vessel comprises steps of: dissolving biodegradable polymer in organic solvent and mixing porogen and manufacturing a polymer/porogen mixed solution; coating a cylindrical shaft with polymer/porogen mixed solution and forming an inner film of a porous coating layer; dissolving the biodegradable polymer in the organic solvent and manufacturing a biodegradable polymer gel; dipping the cylindrical shaft forming the inner film of the porous coating layer, rotating it, falling and radiating the biodegradable polymer gel, winding fiber of a gel state to the inner film of the porous coating layer and forming an outer film of a polymeric fiber layer; separating porosity scaffold of the double-film structure formed in a shaft and removing the organic solvent and the porogen.