OMEGA-5-FATTY ACIDS USEFUL IN LIPOXYGENASE 5 INHIBITION AND IN THE TREATMENT OF CANCER

摘要

Disclosed are omega-5 fatty acids having one of the following formulae: CH3- (CH2) 3-CH=CH- (CH2) 9-COOH, CH3- (CH2) 3-CH=CH- (CH2) 11-COOH, CH3- (CH2) 3-CH=CH- (CH2) 13-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH- (CH2) 6-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH- (CH2) 8-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH- (CH2) 10-COOH, CH3- (CH2)3-CH=CH-CH2-CH=CH-CH2-CH=CH- (CH2) 5-COOH, CH3- (CH2) 3-CH=CH-CH2-CH=CH-CH2-CH=CH- (CH2) 7-COOH, and CH3- (CH2)3-CH=CH-CH2-CH=CH-CH2-CH=CH-CH2-CH=CH- (CH2)4-COOH and pharmaceutically acceptable esters, salts, amides, and solvates thereof, as well as pharmaceutical compositions which include one or more of aforementioned omega-5 fatty acids and pharmaceutically acceptable esters, salts/ amides, and solvates thereof. Also disclosed are methods of inhibiting 5 -lipoxygenase activity; methods of decreasing proliferation of adenocarcinoma cells, or of inducing apoptosis of adenocarcinoma cells, or of inducing differentiation of adenocarcinoma cells into non-cancerous cells; and methods of treating adenocarcinoma in a subject using one or more of aforementioned omega-5 fatty acids and pharmaceutically acceptable esters, salts, amides, and solvates thereof.