NOVEL ARTIFICIAL N-LINKED SIALO-SUGAR CHAIN-CONTAINING POLYMER AND METHOD FOR PRODUCING THE SAME

摘要

It is intended to provide a sialo-sugar chain-containing polymer, which can be synthesized by a practical method capable of achieving a high synthetic yield and has an improved infection inhibitory activity against an influenza virus, and a method for producing the same. An N-linked sialo-sugar chain-containing polymer which is represented by the following structural formula (I) and in which a sialo-sugar chain has been linked to ?-polyglutamic acid via a compound having an amino group and a carboxyl group at an end thereof as a linker. Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is a residue represented by the formula (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 means a hydroxy group or an N-acetylneuraminic acid residue, L means a hydrocarbon, and m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.)