发明名称 |
Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine |
摘要 |
2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia. |
申请公布号 |
US7470784(B2) |
申请公布日期 |
2008.12.30 |
申请号 |
US20050204176 |
申请日期 |
2005.08.16 |
申请人 |
SOUTHERN RESEARCH INSTITUTE |
发明人 |
MONTGOMERY JOHN A.;FOWLER ANITA T.;SECRIST, III JOHN A. |
分类号 |
C07H19/19;C07H19/16 |
主分类号 |
C07H19/19 |
代理机构 |
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