| 摘要 |
1499026 Adriamycin 14-esters SOC FARMACEUTICI ITALIA SpA 16 June 1976 [20 June 1975] 26271/75 Heading C2C Novel adriamycin 14-esters of the general formula wherein X is an O or S atom or an imino group and R is a C 3-20 alkyl group or the radical (obtained by removal of the COOH group) of an aromatic, cyclo - aliphatic, aryl - aliphatic or heterocyclic carboxylic acid of 1-20 carbon atoms, optionally substituted by halogen, hydroxyl, alkyl, alkoxy, nitro, amino or mono- or di-alkyl-amino, and acid addition salts thereof are prepared by reacting 14-bromodaunomycin or an acid addition salt thereof with RCOXCH 2 COOM, wherein M is an alkali or alkaline earth metal. |
