| 摘要 |
NEW MATERIAL:The compound of formula I [X is H or arenesulfonyl; S-x-y are group of formula II (R is H or lower alkyl), etc.]. USE:A synthetic raw material for antibiotic substance chuanghsinmycins and carcinostatic agent. PREPARATION:The compound of formula I can be produced e.g. by adding acetyl chloride to 4-(cyanomethylthio)indole of formula III in a solvent in argon stream to effect 3-acetylation reaction, reacting the reaction product with p- toluenesulfonylhydrazine, etc., dissolving the resultant compound of formula IV (Ts is p-toluenesulfonyl) in diglyme, etc., adding sodium hydride to the solution and thermally refluxing the mixture to effect cyclization reaction.
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