| 摘要 |
A genetically-engineered B oligomer-like multimeric protein of pertussis toxin, useful as a non-reactogenic component in an anti-pertussis vaccine, is produced by expressing the individual cistronic elements for subunits S2, S3, S4, and S5 separately in a heterologous host, recovering the resultant subunit polypeptides, and assembling them by association in vitro to form a multimeric composite. |
