| 摘要 |
PROBLEM TO BE SOLVED: To provide an improved method for producing an amorphous atorvastatin calcium in order to solve the problems that the existing production method of the amorphous atorvastatin includes non-best solvent from the view point of toxicity and environment, and the existing method is non-best from the view point of production ability and is improper in large scale synthesis. SOLUTION: An amorphous atorvastatin hemi calcium salt trihydrate is formed by a method comprising following steps: (a) dissolving the atorvastatin in a solvent to form a solution, and (b) adding the solution in a mixture comprising a non-solvent and a hydroxy solvent to precipitate the atorvastatin from the solution and to obtain the amorphous atorvastatin. COPYRIGHT: (C)2009,JPO&INPIT
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