Platinum complexes as antitumor agents and a pharmaceutical composition comprising the same

摘要

The present invention relates to platinum antitumor drugs. In particular, it relates to platinum complexes having formula Ia or Ib or a pharmaceutically acceptable salt thereof wherein: each A is independently an anion; each B is independently halo, hydroxy, carboxylate, carbamate or a carbonate ester, Z is a substituted 5- or 6-membered, heterocyclic moiety wherein at least one substituent sterically hinders access of the Pt atom to a DNA strand of a tumor cell, and wherein Z is other than pyridine; and X is NH₃ or mono- or dialkyl substituted NH₃. which are active against cancer cells and have improved aqueous solubility and activity.