发明名称 |
DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC SELECTIVE SEROTONIN 5-HT3 BLOCKING AGENT AND ORGANIC ACIDS |
摘要 |
<p>A pharmaceutical dosage form such as a capsule, a conventional or orally disintegrating tablet capable of delivering a weakly basic, nitrogen (N)-containing selective serotonin 5- HT 3 blocking agent having a pKa in the range of from about 5 to 14 and a solubility of not more than about 200 µg/mL at pH 6.8 into the body in a sustained-released fashion, suitable for a once-daily dosing regimen, comprises at least one organic acid, which solubilizes said weakly basic selective serotonin 5-HT 3 blocking agent prior to releasing it into the hostile intestinal environment wherein the blocking agent is practically insoluble. The unit dosage form may be composed of a multitude of multicoated particulates and is designed in such a way that the weakly basic blocking agent and the organic acid do not come into close contact during processing and/or storage thereby avoiding in-situ formation of acid addition compounds while ensuring that the acid is not depleted prior to completion of the drug release.</p> |
申请公布号 |
EP1976491(A2) |
申请公布日期 |
2008.10.08 |
申请号 |
EP20070717465 |
申请日期 |
2007.01.29 |
申请人 |
EURAND, INC. |
发明人 |
VENKATESH, GOPI, M.;LAI, JIN-WANG;VYAS, NEHAL, H. |
分类号 |
A61K9/22;A61K31/4178 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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