发明名称 |
SECRETORY IgA AND IgG ANTIBODIES-INDUCING AGENT |
摘要 |
<p>A nasal vaccine is provided which induces the production of secretory IgA and IgG antibodies specific for flaviviruses, including hantaviruses. Furthermore, a method for providing protection against infection with flaviviruses by induces of the secretory IgA and IgG antibodies is also provided. The nasal vaccine includes an inactivated antigen of a flavivirus and poly(I:C) or a ceramified powder of surf clam shells as an adjuvant. The vaccine effectively induces secretion of IgA antibodies in the nasal mucosa and serum IgG antibody responses. Also provided is a method for inducing flavivirus-specific IgA and IgG antibodies, including administering an inactivated antigen of a flavivirus and poly(I:C) or a ceramified powder of surf clam shells as an adjuvant to the mucosa of a respiratory tract.</p> |
申请公布号 |
EP1932540(A1) |
申请公布日期 |
2008.06.18 |
申请号 |
EP20060810093 |
申请日期 |
2006.09.13 |
申请人 |
MORIYAMA, MASAMI |
发明人 |
MORIYAMA, MASAMI;HASEGAWA, HIDEKI;SATA, TETSUTAROU;KURATA, TAKESHI;TANAKA, TOSHIAKI |
分类号 |
A61K39/12;A61K39/39;A61P11/00;A61P31/12 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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