ANTICOAGULANT PEPTIDES

摘要

The present invention provides an isolated peptide having an amino acid sequence of: (a) [S]<SUB>n</SUB>NYYYVHQNFDRVAYDYDI[U]<SUB>m</SUB> ; or (b) [S]<SUB>n</SUB>KIX<SUP>3</SUP>X<SUP>4</SUP>X<SUP>5</SUP>X<SUP>6</SUP>KX<SUP>8</SUP>X<SUP>9</SUP>[U]<SUB>m</SUB>, wherein X<SUP>3</SUP>, X<SUP>4</SUP> and X<SUP>8</SUP>, and are independently an amino acid selected from A, F, I, L, M, V, W and Y; each of X<SUP>5</SUP>, X<SUP>6</SUP> and X<SUP>9</SUP> is any amino acid; [S] is any amino acid, and n is an integer from (0) to (15); [U] is any amino acid, and m is an integer from (0) to (15). Further, the use of these peptides as anticoagulants is also provided.