ARYLOXY-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES

摘要

Compounds represented by the general formula (I) or pharmaceutically acceptable salts thereof, which have glucokinase activating activity and are useful as therapeutic agents for diabetes and obesity: (I) wherein R1 and R2 are each hydrogen or the like; R3 is hydrogen, halogeno, or the like; R4 is hydrogen, lower alkyl, or the like; Q is a carbon, nitrogen, or sulfur atom (with the proviso that the sulfur atom may be mono- or di-substituted with oxo); R5 and R6 are each hydrogen, lower alkyl, or the like; X1, X2, X3 and X4 are each independently carbon or nitrogen; Z is oxygen, sulfur, or nitrogen; Ar is aryl or heteroaryl; A is a 5- or 6-membered nitrogenous aromatic heterocyclic group; m is an integer of 1 to 6; n is an integer of 0 to 3; p is an integer of 0 to 2 (with the proviso that at least two of X1 to X4 are eac h carbon); and q is 0 or 1.