| 发明名称 |
SEPARATION MATRICES FOR PURIFICATION OF BIOLOGICAL PARTICLES |
| 摘要 |
The invention discloses a separation matrix for purification of biological particles, comprising a plurality of particles having a porous core entity and a porous shell entity covering the core entity, wherein the core entity comprises at least 50 micromole/ml primary amines present on covalently attached ligands displaying at least two primary amines per ligand and the shell entity comprises less than 20 micromole/ml primary amines The invention further discloses a method of purifying biological particles and a method of manufacturing a separation matrix. |
| 申请公布号 |
US2016367966(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201515120845 |
申请日期 |
2015.02.18 |
| 申请人 |
GE HEALTHCARE BIOPROCESS R&D AB |
发明人 |
Maloisel Jean-Luc;Busson Karolina;Lacki Karol;Noren Bjorn;Skoglar Helena |
| 分类号 |
B01J20/32;B01J20/28;B01D15/20;B01D15/30;C12N1/20;B01D15/12;C07K1/22;C07K14/765;C07K14/77;B01J20/286;B01D15/36 |
主分类号 |
B01J20/32 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A separation matrix for purification of biological particles, comprising a plurality of particles having a porous core entity and a porous shell entity covering said core entity, wherein;
a) said core entity comprises at least 50 micromole/ml primary amines present on covalently attached ligands displaying at least two primary amines per ligand and b) said shell entity comprises less than 20 micromole/ml primary amines. |
| 地址 |
Uppsala SE |
