发明名称 |
Protective antigen of epstein barr virus |
摘要 |
The present invention relates to the identification of a subunit vaccine to prevent or treat infection of Epstein Barr Virus. In particular, EBNA-1 was identified as a vaccine antigen. In a specific embodiment, a purified protein corresponding to EBNA-1 elicited a strong CD4<SUP>+</SUP> T cell response. The responsive CD4<SUP>+</SUP> T cell are primarily T<SUB>H</SUB>1 in function. EBNA-1 is an attractive candidate for a protective vaccine against EBV, and for immunotherapy of EBV infection and neoplasms, particularly with dendritic cells charged with EBNA-1.
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申请公布号 |
US7442377(B2) |
申请公布日期 |
2008.10.28 |
申请号 |
US20060359868 |
申请日期 |
2006.02.21 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
STEINMAN RALPH M.;MUENZ CHRISTAN |
分类号 |
A61K39/285;A61K31/7088;A61K31/7105;A61K48/00 |
主分类号 |
A61K39/285 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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