1,2,4-Triazine Derivatives, Preparation and Use Thereof in Human Therapy

摘要

The invention concerns 3,5-dioxo-(2H,4H)-1,2,4-triazine derivatives of general formula (I), wherein: R₁ and R₂, identical or different, represent a branched or linear C₁-C₇ alkyl or alkenyl radical, a C₁-C₆ alkyl radical substituted by groups such as trifluoromethyl, C₅-C₆ cycloalkyl, nitrile, C₁-C₄ alkoxycarbonylvinyl, hydroxycarbonylvinyl, C₁-C₄ alkoxycarbonyl, carboxylate, benzyloxy or phenyl (for which the phenyl ring is optionally substituted by one or more groups such as C₁-C₄ alkoyl, C₁-C₄ alkoxy, nitro, halogen, trifluoromethyl); YR₃ represents oxygen or NR₃ for which R₃ represents hydrogen, a linear or branched C₁-C₇ alkyl or alkenyl radical, a C₁-C₆ alkyl radical substituted by groups such as trifluoromethyl or phenyl (for which the phenyl ring is optionally substituted by one or more groups such as C₁-C₄ alkoyl, C₁-C₄ alkoxy, nitro, halogen, trifluoromethyl); Z represents an oxygen atom or a carbon atom capable of being bound to the ortho, meta or para positions of the phenyl group of formula I; n can be 0 to 5 when Z=C or 2 to 4 when Z=O; X represents oxygen or sulphur; R₄, R₅, R₆, R₇ and R₈ represent hydrogen or fluorine; R₉, R₁₀ and R₁₁ represent hydrogen or a linear or branched C₁-C₅ alkyl group as well as the pharmaceutically acceptable base addition salts, and the various enantiomers of compounds having asymmetric carbons, and their mixtures in all proportions including in particular the racemic mixtures.