A method of Nanoparticle-based therapy for a mammalian subject is disclosed. The method uses Nanoparticles and/or Nanoparticles with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating. The hydrophilic polymer coating is made up of polymer chains either covalently linked or surface adsorbed to the polymer components. After a desired Nanoparticle biodistribution is achieved, the affinity agent binds to the target surface and helps internalize the Nanoparticles
申请公布号
WO2008060734(A3)
申请公布日期
2008.07.10
申请号
WO2007US75968
申请日期
2007.08.15
申请人
NOVARTIS AG;NOVARTIS PHARMA GMBH;KUMAR, SARAN;SHIEH, WEN-CHUNG;TOMER, SEEMA;ZIELINSKI, JOSEPH LAWRENCE
发明人
KUMAR, SARAN;SHIEH, WEN-CHUNG;TOMER, SEEMA;ZIELINSKI, JOSEPH LAWRENCE