发明名称 |
Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b |
摘要 |
<p>The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.</p> |
申请公布号 |
EP1996022(A2) |
申请公布日期 |
2008.12.03 |
申请号 |
EP20070773467 |
申请日期 |
2007.03.22 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
BALTIMORE, DAVID;BOLDIN, MARK;TAGANOV, KONSTANTIN |
分类号 |
C12N15/113;A61K31/713 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|